Silymarin is used to treat hepatic dysfunction.It can also be used as supplementary medication for treating chronic inflammatory diseases such as cirrhosis liver toxicity and liver damage. Side effects that are associated with using this medication are rare. L-Ornithine belongs to Cholagogues and hepatic class. L-Ornithine play key roles in ammonia detoxification and in proline and polyamine biosyntheses. Polyamines are considered critical for DNA synthesis and cell replication and have been shown to stimulate hepatic regeneration.Vitamins and minerals are required in trace amounts and is very useful in promoting certain biochemical reactions.

Indications:

⇒ Used to protect liver cells (and other cells in the body and brain) from toxins.
⇒ Silymarin stimulates liver cell protein synthesis and decreases the oxidation of glutathione.
⇒ Beneficial in a number of diseases involving liver disease
⇒ Powerful liver de- toxifying agent
⇒ Powerful antioxidant
⇒ Healthy appetite
⇒ Hormones and cholesterol production
⇒ Good digestion
⇒ Jaundice

About Composition:

Silymarin: Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Extract contains high amount of silymarin (between 65–80%) that has been concentrated from the milk thistle plant. The silymarin extracted from milk thistle is known to have antioxidant, antiviral and anti-inflammatory properties. It’s regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer. Milk thistle is thought to reduce damage to the liver caused by free radicals, which are produced when your liver metabolizes toxic substances. Its anti-inflammatory and antioxidant properties mean that it is possibly neuroprotective and could help prevent the decline in brain function.

Levocarnitine is used to prevent and treat a lack of carnitine. It is used to prevent and treat this condition in patients with kidney disease on dialysis. It is given to people whose body cannot properly use carnitine from their diet. Lack of carnitine can lead to liver, heart, and muscle problems. Carnitine comes in two forms. Levocarnitine (L-carnitine) should not be confused with the D, L-carnitine form (labeled as “vitamin B T”'). Only the L-form of carnitine is used by the body to treat serious carnitine deficiency. The D, L-form does not help the body use fat and can actually interfere with and cause a lack of levocarnitine.

N-Acetyl L-cysteine (NAC) is a commonly used safe mucolytic drug. NAC increases the cellular levels of antioxidant and reduces glutathione at higher doses. Therefore, NAC has a potential to improve insulin receptor activity in human erythrocytes and improve insulin secretion in response to glucose. Improvement in insulin receptor activity in hyperinsulinemic subjects can lead to a secondary decrease in the ß-cell responsiveness to the oral glucose tolerance test. Advantages resulting from administration of NAC include prevention of endothelial damage resulting from oxidants in noninsulin-dependent adult diabetic subjects and biological effects such as, protection against focal ischemia, inhibition of phospholipid metabolism inhibition, proinflammatory cytokine release, and protease activity. Therefore, effects exerted by NAC at the ovarian level may be as beneficial as its insulin-enhancing effects in inducing ovulation.

L-Glutathione: Glutathione, also known as GSH, is a molecule found naturally in your body. It is synthesized in the liver; glutathione is composed of three amino acids: L-cysteine, glycine, and L-glutamate. Oxidative stress leads to inflammatory bowel diseases such as ulcerative colitis, and glutathione is a key antioxidant in gastrointestinal tissue helps in prevention. Supplements of glutathione helps in reducing vascular stiffness and lowered total cholesterol and low-density lipoprotein (LDL) cholesterol with long-term use.

L-Ornithine, a non-essential and nonprotein amino acid. It is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function. L-Ornithine is metabolised to L-arginine. L-arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of L-arginine in tissues throughout the body. As De novo synthesis of L-arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis. L-ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to L-arginine).

Vitamin E: It is fat soluble Vitamin and is also called as beauty vitamin. Vitamin E shows antioxidant properties, protecting cell membranes from oxidative damage. Due to these effects it is used in the treatment of diseases causing bone loss, cardiovascular diseases, diabetes mellitus and associated comorbidities, eye diseases, inflammatory diseases (including skin conditions), lipid disorders, neurological diseases, and radiation damage.

Vitamin B1:
Vitamin B1 is also known as thiamine. It is a water soluble vitamin. It helps to convert carbohydrate into energy. It is essential vitamin for metabolism of glucose, and it plays a key role in nerve, muscle, and heart function. It is often called an anti-stress vitamin, it protects the immune system and helps to boost your mood.

Vitamin B12 :
⇒ Helps keep the nervous system and red blood cells healthy
⇒ Required for the formation of red blood cells and DNA
⇒ Important for protein metabolism

Choline Bitartrate is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. Choline also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. Choline is a major part of the polar head group of phosphatidylcholine and maintains the integrity of cell membrane.

Vitamin B2:
⇒ Helps convert food into energy.
⇒ Required for red blood cell production and growth.
⇒ Maintains the function of eyes, nervous system, and skin.

Inositol is often referred to as vitamin B8, but it is not actually a vitamin. It’s a type of sugar that influences the insulin response and several hormones associated with mood and cognition. Inositol also has antioxidant properties that fight the damaging effects of free radicals in the brain, circulatory system, and other body tissues.

Calcium Pantothenate:
⇒ It is form of panthothenic acid or vitamin b5
⇒ Breaks down fats and carbohydrates for energy
⇒ Plays a role in the production of sex and stress hormones in the adrenal glands and neurotransmitters
⇒ Vitamin B5 is needed for the production of red blood cells and cholesterol

Folic Acid is a type of B vitamin helps your body produce and maintain new cells, and also helps prevent changes to DNA that may lead to cancer. Folic acid is sometimes used in combination with other medications to treat pernicious, aplastic, or normocytic anemia.

Vitamin C is needed by the body to form collagen. The body also uses vitamin C to make skin, tendons, ligaments and blood vessels. It also uses this vitamin to repair and maintain cartilage, bones and teeth, to heal wounds and to form scar tissue.

Vitamin B6 or Pyridoxine:
Pyridoxine has been used to treats peripheral neuropathy caused by certain drugs such as isoniazid. It has also been used to treat certain genetic disorders such as xanthurenic aciduria, hyperoxaluria. It is one of the major vitamin required by red blood cells.

Vitamin D3 helps your body absorb calcium. Vitamin D3 is used as a dietary supplement in people who do not get enough vitamin D in their diets to maintain adequate health. Vitamin D is used to treat and prevent bone disorders (such as rickets, osteomalacia).

Zinc: It help is synthesis of more than 70 different enzymes. Zinc containing enzymes regulates metabolism of carbohydrates, lipids, and proteins. Zinc fastens wound healing; maintain normal growth rates, balance skin hydration and the senses of taste and smell. It assists normal growth and tissue repair. It boosts cell mediated immunity. It is poorly absorbed when given orally. Zinc is well distributed in tissues lik skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Zinc is mainly excreted through intestine and only 2% loss in the urine.

Iron is the major ingredient of red blood cell and is used in anaemia.

Copper: It is the third most abundant essential trace mineral, and is required as cofactor for many proteins, iron utilization enhancer. Copper, along with amino and fatty acids as well as vitamins, are required for normal metabolic processes. It is well orally absorbed.

Selenium is nutritionally essential for humans, is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection. Selenium has attracted attention because of its antioxidant properties. Antioxidants protect cells from damage. It can be used for many disorders like asthma to arthritis to dandruff to infertility and may reduce the odds of prostate cancer.

Co-enzyme Q10 act as the cofactor in the mitochondrial electron transport chain. It accepts the electrons from the complex I and II and produces the adenosine triphosphate and protects the peroxidation of lipid membranes as well as inhibits the oxidation of LDL -cholesterol.

Side Effects:

The product is possible safe for most adults. There is no disadvantage associated with the product if taken under the recommended usage however common side effects include Gas, constipation, loose stool, and loss of appetite sometimes happen, especially at the beginning of the regimen.

Contraindication:

⇒ Avoid alcohol consumption
⇒ Do not take antacid along with the supplements
⇒ Renal or hepatic impairment

Precaution:

⇒ Do not exceed the recommended dose
⇒ Keep out of reach of children
⇒ The combination should only be used in pregnancy and lactation if benefits outweigh the risks.